Capsaicin in human experimental pain models of skin, muscle and visceral sensitization

摘要: It has always been the dream of pain researchers and clinicians to have objective measures phenomena such as hyperalgesia. Unfortunately, this is not yet possible will most likely never be. Pain a multidimensional, unpleasant sensory emotional experience cannot be represented or described by single parameter number. However, different possibilities exist assess quantitatively various aspects complex related By measuring combination measurements more can learned about which dimensions are affected, mechanisms/pathways impaired functioning normally [1]. The ultimate goal pain-assessment procedures obtain better understanding mechanisms (e.g. hyperalgesia) involved in transduction, transmission perception under normal pathophysiological conditions, either patients after experimentally induced sensitization volunteers. Assessment evaluation peripheral central divided into four main categories (Fig. 1): – assessment ongoing clinical pain; evoked for diagnosis monitoring patients; basic studies healthy volunteers conditions; conditions with hyperalgesia (for example, capsaicin).