Does the preclinical evidence for functional remyelination following myelinating cell engraftment into the injured spinal cord support progression to clinical trials

摘要: This article reviews all historical literature in which rodent-derived myelinating cells have been engrafted into the contused adult rodent spinal cord. From 2500 initial PubMed citations identified, human grafts, bone mesenchymal stem cells, olfactory ensheathing non-myelinating cell and grafts hemisection or transection models were excluded, resulting 67 studies encompassed this review. Forty five of those involved central nervous system (CNS)-derived including neural progenitor (NSPCs), restricted precursor (NRPs) oligodendrocyte (OPCs), 22 Schwann (SC). Of NSPC/NPC/OPC there was no consistency with respect to types grafted and/or additional growth factors co-grafted. Enhanced functional recovery reported 31/45 studies, but only 20 had appropriate controls making conclusive interpretation remaining impossible. 20, 19 properly powered utilized statistical analyses. Ten presence graft-derived myelin, 3 evidence endogenous remyelination myelin sparing, 2 both. For SC 16/21 improvement, 11 having cellular 9/11 using proper 9, increased 6 studies. The lack replication among these preclinical are discussed progression transplantation therapies clinic.