Utility of the cumulative stress and mismatch hypotheses in understanding the neurobiological impacts of childhood abuse and recent stress in youth with emerging mental disorder

摘要: Childhood abuse has an enduring impact on the brain's stress system. Whether effects of childhood and adulthood are additive (cumulative hypothesis) or interactive (mismatch is widely disputed, however. The primary aim this study was to test utility cumulative mismatch hypotheses in understanding brain behaviour. We recruited 64 individuals (aged 14-26) from a specialised clinic for assessment early intervention mental health problems young people. A T1-weighted MRI, resting state fMRI clinical were acquired each participant. Grey matter estimates functional connectivity (rsFC) hippocampus, amygdala anterior cingulate cortex (ACC) determined using segmentation seed-to-voxel rsFC analyses. explored recent structure function regions interest within general linear models. Worse psychiatric symptoms significantly related higher levels life time stress. Individuals with mismatched had reduced left hippocampal volume, ACC-ventrolateral prefrontal greater ACC-hippocampus rsFC, compared matched levels. These results show specific hypothesis symptomatology modelling grey matter, prefrontal-hippocampal rsFC. provide novel evidence reactivity population, demonstrate distinct different systems. Hum Brain Mapp 38:2709-2721, 2017. © 2017 Wiley Periodicals, Inc.