Preservation of Endogenous Antioxidant Activity and Inhibition of Lipid Peroxidation as Common Mechanisms of Antiatherosclerotic Effects of Vitamin E, Lovastatin and Amlodipine

摘要: Abstract Objectives. We sought to document the common mechanisms of antiatherogenic effects cholesterol-lowering hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor lovastatin, dihydropyridine Ca2+blocker amlodipine and antioxidant vitamin E. Background. Vitamin E, HMG-CoA inhibitors Ca2+blockers each inhibit atherosclerosis in hypercholesterolemic animals. Methods. New Zealand White rabbits were fed regular chow (Group A), with 1% cholesterol B), diet plus lovastatin C), E D) or E) for 12 weeks. The extent aortic was measured by planimetry sudanophilic area. Malondialdehyde (MDA) superoxide dismutase (SOD) blood as indexes lipid peroxidation activity, respectively. Results. Group showed no atherosclerosis, whereas B had 17.4 ± 9.3% (mean SD) aorta covered Groups C, D significantly less atherosclerosis. Plasma SOD activity lower than (6.9 1.1 vs. 12.8 1.5 U/ml, p Conclusions. This study suggests that a reduction preservation may be antiatherosclerotic amlodipine.