Clinical review: Pituitary carcinoma: difficult diagnosis and treatment.

摘要: Context: Although pituitary tumors are common, carcinoma is very rare and only diagnosed when tumor noncontiguous with the sellar region demonstrated. Diagnosis difficult, resulting in delays that may adversely effect outcome traditionally poor. Barriers to earlier diagnosis management strategies for discussed. Evidence Acquisition: PubMed was employed identify relevant studies, a review of literature conducted, data were summarized integrated from author's perspective. Synthesis: The available highlight difficulties practical challenges conducting clinical trials this condition. They suggest aggressive multimodal therapy be advantageous some cases. Conclusions: remains difficult diagnose treat, recent developments have led improved outcomes selected With broader use molecu...