Rearrangement of the bcr Gene in Philadelphia-Chromosome-Negative Chronic Myeloid Leukemia
作者： TS Ganesan , F Rassool , AP Guo , KH Th'ng , C Dowding
DOI: 10.1007/978-3-642-72624-8_33
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摘要: The majority of patients with chronic myeloid leukaemia (CML) have a characteristic deletion portion the long arm one chromosome 22, Philadelphia (Ph 1) chromosome, in their cells. missing material is reciprocally translocated to 9 such that usual karyotype described as t(9;22)(q34;q11). In Ph 1-positive CML, oncogene (c-abl) normally present on 22 [1, 2] where it comes into juxtaposition region named “breakpoint cluster region” (bcr) [3]. A chimeric abl-related mRNA has been identified cells from CML [4] and associated presence fusion protein tyrosine kinase activity [5]. Thus, show evidence rearrangement DNA within bcr region.
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