The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities.

摘要: PURPOSE To compare the sensitivity of volume scanning with optical coherence tomography (OCT) to nonmydriatic color fundus photography (FP) for detection retinal irregularities in asymptomatic populations. METHODS Asymptomatic subjects without known ocular disease were recruited over a 6-month period. For each eye, two undilated 45° images and four OCT image sets covering macula optic nerve obtained. Color evaluated both inside outside area covered by OCT. internal limiting membrane irregularities, abnormal thickness, hyper/hyporeflective features, photoreceptor/retinal pigment epithelium (RPE) irregularities. Detection sensitivities compared false-negative cases analyzed. RESULTS A total 284 eyes (144 subjects) included, mean age 38.1 years (range 18-77). Among 253 (135 gradable from FP OCTs, higher (96.2% infield 85.7% full field) than (19.9% 43.8% all study (including epiretinal intraretinal hyperreflective/hyporeflective photoreceptor/RPE irregularities). Overall, presence definite on either imaging or eye this population was 42.6% (121/284), 39.4% (112/284) having RPE such as drusen. CONCLUSIONS variety current study, more sensitive our individuals. detected clinically relevant subretinal fluid, that missed FP, had lower ungradable rate. It is likely will be added screening near future chorioretinal disease.