Pathogenesis of thrombosis: cellular and pharmacogenetic contributions
作者： Dileep D. Monie , Emma P. DeLoughery
关键词:
摘要: Our understanding of thrombosis formation has evolved significantly ever since physician Rudolf Virchow proposed his "triad" theory in 1856. Modern science elucidated the mechanisms stasis, hypercoagulability, and endothelial dysfunction. Today, we have a firm key molecular factors involved coagulation cascade fibrinolytic system, as well underlying genetic influences. This knowledge cellular contributors been translated into diverse pharmaceutical interventions. Here, examine its associated pathologies. We also review current state pharmacologic interventions, including pro- anti-thrombotics, direct oral anticoagulants, anti-platelet therapies. The pharmacogenetic that guide clinical decision making prognosis are described detail. Finally, explore new approaches to drug discovery, repurposing, diagnostics. argue network biology tools will enable systems pharmacology revolution next generation facilitating precision medicine applications ultimately leading improved patient outcomes.
amegroups.com参考文章(36)
Xiangjun Kong, Wenxia Zhou, Jian-Bo Wan, Qianru Zhang, Jingyun Ni, Yuanjia Hu, An Integrative Thrombosis Network: Visualization and Topological Analysis Evidence-based Complementary and Alternative Medicine. ,vol. 2015, pp. 265303- 265303 ,(2015) , 10.1155/2015/265303
Rogier M. Bertina, The role of procoagulants and anticoagulants in the development of venous thromboembolism Thrombosis Research. ,vol. 123, pp. S41- S45 ,(2009) , 10.1016/S0049-3848(09)70142-2
Jiny Nair, Madankumar Ghatge, Vijay V. Kakkar, Jayashree Shanker, Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease. PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0094328
Charles T. Esmon, Basic mechanisms and pathogenesis of venous thrombosis. Blood Reviews. ,vol. 23, pp. 225- 229 ,(2009) , 10.1016/J.BLRE.2009.07.002
Scarparo Pamela, Lombardi Anna Maria, Duner Elena, Malerba Giovanni, Allemand Emanuele, Vettore Silvia, Blumentritt Carmen, Greinacher Andreas, Fabris Fabrizio, Heparin-induced thrombocytopenia: The role of platelets genetic polymorphisms Platelets. ,vol. 24, pp. 362- 368 ,(2013) , 10.3109/09537104.2012.701026
Johannes J. Sidelmann, Sven O. Skouby, Cornelis Kluft, Ulrich Winkler, Frank Vitzthum, Herbert Schwarz, Jørgen Gram, Jørgen Jespersen, Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo. Thrombosis Research. ,vol. 128, ,(2011) , 10.1016/J.THROMRES.2011.06.013
Jason H. Karnes, Robert M. Cronin, Jerome Rollin, Alexander Teumer, Claire Pouplard, Christian M. Shaffer, Carmelo Blanquicett, Erica A. Bowton, James D. Cowan, Jonathan D. Mosley, Sara L. Van Driest, Peter E. Weeke, Quinn S. Wells, Tamam Bakchoul, Joshua C. Denny, Andreas Greinacher, Yves Gruel, Dan M. Roden, A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record Thrombosis and Haemostasis. ,vol. 113, pp. 772- 781 ,(2014) , 10.1160/TH14-08-0670
Anna Luisa Di Stefano, Marianne Labussiere, Giuseppe Lombardi, Marica Eoli, Donata Bianchessi, Francesco Pasqualetti, Patrizia Farina, Stefania Cuzzubbo, Jaime Gallego-Perez-Larraya, Blandine Boisselier, Francois Ducray, Caroline Cheneau, Arrigo Moglia, Gaetano Finocchiaro, Yannick Marie, Amithys Rahimian, Khe Hoang-Xuan, Jean Yves Delattre, Karima Mokhtari, Marc Sanson, None, VEGFA SNP rs2010963 is associated with vascular toxicity in recurrent glioblastomas and longer response to bevacizumab. Journal of Neuro-oncology. ,vol. 121, pp. 499- 504 ,(2015) , 10.1007/S11060-014-1677-X
W. C. AIRD, Vascular bed-specific thrombosis. Journal of Thrombosis and Haemostasis. ,vol. 5, pp. 283- 291 ,(2007) , 10.1111/J.1538-7836.2007.02515.X
Yuval Ramot, Abraham Nyska, Drug-induced thrombosis--experimental, clinical, and mechanistic considerations. Toxicologic Pathology. ,vol. 35, pp. 208- 225 ,(2007) , 10.1080/01926230601156237