Neuromodulatory functions of the endocannabinoid system.

摘要: The endocannabinoid system (ECS) has recently emerged as an important neuromodulatory in the brain. Several neuronal functions are under control of cannabinoid receptor type 1 (CB1 receptor) and its endogenous lipid ligands (endocannabinoids). CB1 receptors widely expressed brain their expression pattern reflects complexity variety ECS activity. In particular, present at different levels several regions distinct subpopulations. Endocannabinoids were described to act retrograde transmitters synaptic level many regions. Interestingly, mechanisms governing endocannabinoid-controlled modulation can vary depending on region circuit. At physiological pathophysiological level, been shown play regulatory roles processes, including memory processing excessive discovery represents a hallmark neuroscience research, exploitation numerous is promising avenue for therapeutic applications.