Differing myocardial response to a single session of hemodialysis in end-stage renal disease with and without type 2 diabetes mellitus and coronary artery disease

摘要: Though hemodialysis (HD) acutely improves cardiac function, the impact of background diseases like coronary artery disease (CAD) and Type 2 diabetes (DM) in setting end-stage renal (ESRD) is not known. Tissue velocity echocardiography (TVE) offers a fast choice to follow changes myocardial function after HD ESRD with concomitant DM /or CAD. 46 subjects (17 ESRD, Group 1; 15 DM, 2; 14 DM+CAD, 3) underwent standard TVE prior shortly HD. Besides Doppler variables, regional systolic diastolic velocities, as well strain rate were post processed. Compared pre-HD, post-HD body weight (kg) significantly decreased all three groups (51 ± 9 vs. 48 8, 62 10 vs.59 10, 61 58 respectively; p < 0.01). Left ventricular end dimensions (mm) also post- (46 5 42 7, 53 7 50 51 47 8 Regional longitudinal peak septum (cm/s) increased 1(5.7 1.6 7.2 2.3; 0.001) while remained unchanged other two groups. Similar trends noted left walls. When velocities computed globally, improvement was seen only 1 (6.3 1.5 7.9 2.0; 0.001). Global early improved 1, 2, 3(-5.9 1.3 -4.1 1.8; (1/sec) first Groups but (-0.87 0.4 -0.94 0.3; = ns) 3. A single session LV without coexistent and/or The present data suggest that dialysis-dependent loading conditions co-existent determine response