Phase-Dependent Modulation of Percutaneously Elicited Multisegmental Muscle Responses After Spinal Cord Injury
作者： Christine J. Dy , Yury P. Gerasimenko , V. Reggie Edgerton , Poul Dyhre-Poulsen , Grégoire Courtine
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摘要: Phase-dependent modulation of monosynaptic reflexes has been reported for several muscles the lower limb uninjured rats and humans. To assess whether this step-phase-dependent can be mediated at level human spinal cord, we compared responses evoked simultaneously in multiple motor pools clinically complete cord injury (SCI) with noninjured (NI) individuals. We induced multisegmental soleus, medial gastrocnemius, tibialis anterior, hamstring, vastus lateralis response to percutaneous stimulation over Th11-Th12 vertebrae during standing stepping on a treadmill. Individuals SCI stepped treadmill partial body-weight support manual assistance leg movements. The NI group demonstrated phase-dependent potentials all recorded amplitude corresponding changes EMG same muscle. more variation pattern across step cycle individuals could display magnitude as great that observed group. relationship between activity varied from noncorrelated highly correlated patterns. These findings demonstrate lumbosacral phase-dependently modulate neuron excitability absence functional supraspinal influence, although much less consistency than
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