Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders

摘要: The autophagy-lysosomal pathway is a major proteolytic that in mammalian systems mainly comprises of macroautophagy and chaperone-mediated autophagy. former relatively non-selective involves bulk degradation proteins organelles, whereas the latter selective for certain cytosolic proteins. These autophagy pathways are important development, differentiation, cellular remodeling survival during nutrient starvation. Autophagy crucial neuronal homeostasis acts as local housekeeping process, since neurons post-mitotic cells require effective protein to prevent accumulation toxic aggregates. A growing body evidence now suggests dysfunction causes abnormal and/or damaged organelles. Such has been linked synaptic dysfunction, stress death. Abnormal may be involved pathology both chronic nervous system disorders, such proteinopathies (Alzheimer's, Parkinson's, Huntington's disease) acute brain injuries. Although generally beneficial, its aberrant activation also exert detrimental role neurological diseases depending on environment insult, leading autophagic In this review we summarize current knowledge regarding central discuss implication dysregulation human animal models.