Immune response activation following hyperthermic intraperitoneal chemotherapy for peritoneal metastases: A pilot study.
作者： Giammaria Fiorentini , Donatella Sarti , Alberto Patriti , Emilio Eugeni , Francesco Guerra
关键词:
摘要: Background Hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases (PM) is considered to be feasible, safe and improve survival. Aim To investigate whether an immune response activated following HIPEC PM. Methods Six patients were enrolled in this study. Peripheral blood samples obtained from each patient prior (day 0) post-procedure 30), used evaluate the number of CD3+ total, CD3+/CD4+ T-Helper, CD3+/CD8+ cytotoxic T, CD3+/CD56+ natural killer CD19+ B lymphocyte numbers, CD4+: CD8+ T ratios. Results The total numbers CD3+, lymphocytes, ratios increased all but one 30 d cytoreductive surgery-HIPEC procedure, these increases significant (P ≤ 0.05) Helper numbers. Conclusion This report provides first evidence that exhibits immunomodulating activity PM patients, resulting generalized activation adaptive response. Moreover, majority populations continued elevated several weeks consistent with a potential authentic effect rather than normal inflammatory response, fully characterised future studies.
sci-hub.st 参考文章(18)
Giorgos C. Karakousis, H. Richard Alexander, Madalyn G. Neuwirth, Then and now: cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), a historical perspective Journal of gastrointestinal oncology. ,vol. 7, pp. 18- 28 ,(2016) , 10.3978/J.ISSN.2078-6891.2015.106
Yvonne LB Klaver, Valery EPP Lemmens, Simon W Nienhuijs, Misha DP Luyer, Ignace HJT de Hingh, None, Peritoneal carcinomatosis of colorectal origin: Incidence, prognosis and treatment options World Journal of Gastroenterology. ,vol. 18, pp. 5489- 5494 ,(2012) , 10.3748/WJG.V18.I39.5489
Li Ma, Zhaolie Chen, Xiaoning Wang, Qiang Sun, Meifang He, Hongyan Huang, Manna Wang, Ang Chen, Xiangkai Ning, Kaitao Yu, Qihong Li, Wen Li, Fluorescence-Activated Cell Sorting Analysis of Heterotypic Cell-in-Cell Structures Scientific Reports. ,vol. 5, pp. 9588- 9588 ,(2015) , 10.1038/SREP09588
Vic J. Verwaal, Serge van Ruth, Eelco de Bree, Gooike W. van Slooten, Harm van Tinteren, Henk Boot, Frans A.N. Zoetmulder, Randomized Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy and Palliative Surgery in Patients With Peritoneal Carcinomatosis of Colorectal Cancer Journal of Clinical Oncology. ,vol. 21, pp. 3737- 3743 ,(2003) , 10.1200/JCO.2003.04.187
Y. W. Novitsky, D. E. M. Litwin, M. P. Callery, The net immunologic advantage of laparoscopic surgery Surgical Endoscopy and Other Interventional Techniques. ,vol. 18, pp. 1411- 1419 ,(2004) , 10.1007/S00464-003-8275-X
Katrina F. Chu, Damian E. Dupuy, Thermal ablation of tumours: biological mechanisms and advances in therapy. Nature Reviews Cancer. ,vol. 14, pp. 199- 208 ,(2014) , 10.1038/NRC3672
Joerg OW Pelz, Terence C Chua, Jesus Esquivel, Alexander Stojadinovic, Joerg Doerfer, David L Morris, Uwe Maeder, Christoph-Thomas Germer, Alexander G Kerscher, Evaluation of Best Supportive Care and Systemic Chemotherapy as Treatment Stratified according to the retrospective Peritoneal Surface Disease Severity Score (PSDSS) for Peritoneal Carcinomatosis of Colorectal Origin BMC Cancer. ,vol. 10, pp. 689- 689 ,(2010) , 10.1186/1471-2407-10-689
Charlotte EL Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis JA Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer, Ignace HJT de Hingh, Laureen A Lammers, Barbara L van Leeuwen, Wilhelmus JHJ Meijerink, Simon W Nienhuijs, Jolien Pon, Sandra A Radema, Bert van Ramshorst, Petur Snaebjornsson, Jurriaan B Tuynman, Elisabeth A Te Velde, Marinus J Wiezer, Johannes HW de Wilt, Pieter J Tanis, None, Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial BMC Cancer. ,vol. 15, pp. 428- 428 ,(2015) , 10.1186/S12885-015-1430-7
Andrew C Leon, Lori L Davis, Helena C Kraemer, None, The role and interpretation of pilot studies in clinical research Journal of Psychiatric Research. ,vol. 45, pp. 626- 629 ,(2011) , 10.1016/J.JPSYCHIRES.2010.10.008
Fumito Ito, Amy W. Ku, Mark J. Bucsek, Jason B. Muhitch, Trupti Vardam-Kaur, Minhyung Kim, Daniel T. Fisher, Marta Camoriano, Thaer Khoury, Joseph J. Skitzki, Sandra O. Gollnick, Sharon S. Evans, Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer PLOS ONE. ,vol. 10, pp. e0143370- ,(2015) , 10.1371/JOURNAL.PONE.0143370