Electrophysiological Properties of Dural Afferents in the Absence and Presence of Inflammatory Mediators

摘要: Migraine is a debilitating condition characterized by recurrent severe head pain. Although mechanisms underlying migraine attack remain controversial, one proposal that inflammatory mediator (IM)–induced activation and sensitization of dural afferents contribute to the initiation We others have shown electrophysiological properties afferents, both in absence presence IM, vary as function target innervation. These differences may account for unique aspects pain syndromes associated with specific body regions. Therefore purpose present study was test hypothesis differ from those innervating temporalis muscle (TM), structure close proximity dura but not at all similar migraine. Acutely dissociated retrograde labeled primary TM were examined whole cell current-clamp recordings. Passive active determined before after application IM: (in μM) prostaglandin E2 (1), bradykinin (10), histamine (1). In there significant between two populations, particularly respect response suprathreshold stimulation where more excitable than afferents. Importantly, although populations sensitized pattern passive changes IM-induced these suggested similarities marked sensitization. If are due differential ion channel expression rather relative density/biophysical same channels, it be possible selectively treat targeting distinct