Improving the accuracy of pancreatobiliary tract cytology with fluorescence in situ hybridization

摘要: The detection of aneuploidy by fluorescence in situ hybridization (FISH) has revolutionized how laboratories diagnose cholangiocarcinoma and pancreatic adenocarcinoma using cytology specimens. Numerous clinical studies have demonstrated that FISH increases the diagnostic sensitivity routine for detecting pancreatobiliary tract malignancy with minimal decreases specificity. also provides useful information difficult scenarios, including assessment patients biliary strictures who equivocal results primary sclerosing cholangitis features suggestive malignancy. improved ability to detect cancers offers possibility earlier when are amenable surgical intervention can decrease health care costs reducing amount evaluation required arrive at a cancer diagnosis. Cytopathology personnel should maintain familiarity molecular testing methodologies, because morphologic tumors will continue be an integral part large-scale genome analyses individual tumors. Cancer (Cancer Cytopathol) 2013;121:610-9. © 2013 American Society.