Effects of 5-Amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one Intake on Digestive System in a Rat Model of Colon Cancer

摘要: Introduction. Pyrrol derivate 5-amyno-4-(1,3-benzothyazol-2-yn)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one (D1) has shown antiproliferative activities in vitro, so investigation of the impact D1 intake on gut organs rats that experienced colon cancer seems to be necessary. Materials and Methods. at dose 2.3 mg/kg was administered per os daily for 27 (from 1st day experiment) or 7 21st week weeks 1,2-dimethylhydrazine (DMH)-induced 20 weeks. 5-Fluorouracil (5FU) chosen as reference drug intraperitoneally weekly 45 mg/kg. Results. Antitumor activity comparable with 5FU one against DMH-induced observed (decrease tumor number total area up 46%). attenuated inflammation colon, gastric jejunal mucosa, liver, caused by DMH, unlike 5FU, aggravating latter. In addition, partially normalized mucosa morphometric parameters suggesting its functional restore. Conclusions. possesses, 5-fluorouracil antitumor efficacy, less damaging effects tissues beyond cancerous areas contributes partial morphological recovery.