Role of protease-activated receptor 2 in lung injury development during acute pancreatitis in rats.
作者： Enrique de-Madaria , María del Mar Francés , Sabrina Gea-Sorlí , Luis M. Gutiérrez , Salvador Viniegra
DOI: 10.1097/MPA.0000000000000152
关键词:
摘要: OBJECTIVE The objective of this study was to evaluate whether an uncontrolled activation mast cells and macrophages through protease-activated receptor-2 (PAR-2) during acute pancreatitis could develop lung injury. METHODS Pancreatitis induced in rats by intraductal infusion sodium taurocholate. In a group animals, PAR-2 antagonist or trypsin (TRP) inhibitor intravenously administered before the induction. additional groups, animals were treated with PAR-2-activating peptide pancreatic TRP. myeloperoxidase (MPO) activity measured progression inflammation. RESULTS Plasma from TRP secretion alveolar as well increased density plasma membrane. treatment TRP, tryptase, PAR-1- led increase calcium-triggered exocytosis. Similar results obtained acinar cells. intravenous injection MPO lung. induction prevent pancreas CONCLUSIONS generated be involved injury macrophages.
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