Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor.
作者： M. Josephina Coloma , Hwa Jeong Lee , Atsushi Kurihara , Elliot M. Landaw , Ruben J. Boado
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摘要: Purpose. Brain drug targeting may be achieved by conjugating drugs,that normally do not cross the blood-brain barrier (BBB), to brain drugdelivery vectors. The murine 83-14 MAb human insulin receptor(HIR) is a potential vector that could used inhumans, if this was genetically engineered form chimericantibody, where most of immunogenic sequences arereplaced antibody sequence.
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sci-hub.se 参考文章(27)
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