Gonadal-hypothalamic interaction in prepubertal and pubertal man: effect of clomiphene citrate on urinary follicle-stimulating hormone and luteinizing hormone and plasma testosterone.

摘要: Extract: The effect of administering various doses clomiphene citrate upon gonadotropin excretion and plasma testosterone in 13 prepubertal pubertal patients both sexes was evaluated. Follicle-stimulating hormone (FSH) luteinizing (LH) were measured by the radioimmunoassay urinary kaolin-acetone extracts. Clomiphene suppressed FSH two five given 0.1 mg/day for 1 week. There neither stimulatory nor suppressive effects when 0.01 or 0.001 drug administered. Urinary gonadotropins decreased 100 administered to early individuals. Neither stimulation suppression took place 10 mg, patients. In girls midpuberty who received clomiphene, an LH rise observed, these individuals experienced menarche 17–24 days after beginning ingestion. Sequential studies a boy between mid puberty revealed change results from no response data are consistent with hypothesis that hypothalamus child is sensitive negative feedback weak estrogen, clomiphene. Not until can similar those obtained adult, be demonstrated. Speculation: Presumably there marked sensitivity hypothalamic-pituitary centers gonadal steroids during sexual maturation. Since set-point continues decrease puberty, may fact begin childhood. Puberty might then viewed as continuum lasting several years, secondary characteristics only critical level steadily increasing secretion attained.