Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women

摘要: OBJECTIVES: To compare two methods for classifying an individual as sarcopenic predicting decline in physical function the Health, Aging and Body Composition Study. DESIGN: Observational cohort study with 5 years of follow-up. SETTING: Communities Memphis, Tennessee, Pittsburgh, Pennsylvania. PARTICIPANTS: Men women aged 70 to 79 (N=2,976, 52% women, 41% black). MEASUREMENTS: Appendicular lean mass (aLM) was measured using dual energy x-ray absorptiometry, participants were classified first aLM divided by height squared then adjusted body fat (residuals). Incidence persistent lower extremity limitation (PLL) according self-report, change objective performance (LEP) measures observed Short Physical Performance Battery. RESULTS: There a greater risk incident PLL who residuals sarcopenia method than not (hazard ratio (HR)=1.34, 95% confidence interval (CI)=1.11–1.61) but men. Those defined aLM/ht2 had nonsarcopenic men (HR=0.76, CI=0.60–0.96) (HR=0.75, CI=0.60–0.93), these no longer significant adjustment mass. Using method, there significantly poorer LEP scores at baseline Year 6 5-year decline, whereas decline. Additional attenuated this protective effect. CONCLUSION: These findings suggest that considers together, is better disability because it part definition.