Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence.

摘要: Impulsivity is a risk factor for alcoholism, and long-term alcohol exposure may further impair impulse control in manner that propels problematic use. The present study employed the rat 5-choice serial reaction time task (5-CSRTT) to measure behavioral inhibition attentional capacity during abstinence from repeated 5-day cycles of liquid diet consumption. Task performance was not disrupted following first cycle exposure; however, evidence impaired emerged third exposure. In comparison with controls, alcoholic rats exhibited deficits inhibitory cognitively challenging 5-CSRTT tests employing variable intertrial interval (varITI). This disruption early (3 days) but evident by 7 days persisted at least 34 days. Interestingly, renewed consumption ameliorated these disruptions control, although deficient re-emerged subsequent abstinence. Indices increased impulsivity were no longer conducted after 49 Alcohol-related impairments sessions highly familiar parameters regardless period, experiments confirmed challenge unlikely result alcohol-related adaptation varITI testing. Together, current findings demonstrate chronic intermittent results decreased temporally similar clinical observations impulsive abstinent alcoholics performing tasks inhibition.