The role of 131 iodine-metaiodobenzylguanidine scanning in the correlative imaging of patients with neuroblastoma

摘要: Objective. Metaiodobenzylguanidine (MIBG) scans were studied to determine the impact of scan results on clinical treatment pediatric patients with neural crest tumors. Methods. Serial reviewed retrospectively for 27 tumors: 25 initial diagnoses neuroblastoma (NB), 1 ganglioneuroblastoma, and ganglioneuroma (GN). Results compared bone computed tomography scans, as well surgical pathologic findings. Results. At diagnosis, when tomographic MIBG imaging did not identify any unsuspected lesions that resulted in a change staging. Thirteen NB who had initially positive serial studies normalized during therapy. However, after completion therapy, 8 13 relapses disease. Although areas active disease delineated by other standard modalities all 8, only 4 (50%) study sites relapse. There cases GN (1 at diagnosis 3 therapy NB) demonstrating an uptake was similar appearance NB. Conclusions. staging or alter patient. Normalization unreliable indicator outcome children Furthermore, relapse occurred, identified 50% those The indistinguishable from In this series, have significant patient treatment.