Development of nanoemulsions for topical delivery of vitamin K1.
作者： Virginia Campani , Marco Biondi , Laura Mayol , Francesco Cilurzo , Michele Pitaro
DOI: 10.1016/J.IJPHARM.2016.07.004
关键词:
摘要: Vitamin K1 (VK1) is a natural and lipophilic compound currently used in dermatological formulations. In this work, nanoemulsions containing VK1 have been proposed to overcome some issues associated semisolid VK1-incorporating The study has focused on the design of lipid-free aqueous formulation, easy prepare with low cost production. Thus, simply protocol, using low-energy method, spontaneously form nanoemulsions. nanoemulsion composition optimized improve its physical stability during storage different conditions. Then, possibility administer VK1-containing by nebulization without significant alteration formulation was tested. Moreover, accumulation into skin layers evaluated through permeation experiments Franz cells, ATR-FITR analysis, confocal laser scanning microscopy (CLSM) observations, high performance liquid chromatography (HPLC) analysis. demonstrated that NEs represent an interesting option for commercial development spray topical delivery VK1.
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A. Gillet, F. Lecomte, P. Hubert, E. Ducat, B. Evrard, G. Piel, Skin penetration behaviour of liposomes as a function of their composition. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 79, pp. 43- 53 ,(2011) , 10.1016/J.EJPB.2011.01.011
Fabienne Damien, Mila Boncheva, The Extent of Orthorhombic Lipid Phases in the Stratum Corneum Determines the Barrier Efficiency of Human Skin In Vivo Journal of Investigative Dermatology. ,vol. 130, pp. 611- 614 ,(2010) , 10.1038/JID.2009.272
Luciana B Lopes, Fernanda FF Speretta, M Vitória LB Bentley, None, Enhancement of skin penetration of vitamin K using monoolein-based liquid crystalline systems European Journal of Pharmaceutical Sciences. ,vol. 32, pp. 209- 215 ,(2007) , 10.1016/J.EJPS.2007.07.006
O. Sonneville-Aubrun, J.-T. Simonnet, F. L'Alloret, Nanoemulsions: a new vehicle for skincare products Advances in Colloid and Interface Science. ,vol. 108, pp. 145- 149 ,(2004) , 10.1016/J.CIS.2003.10.026
Giuseppe De Rosa, Virginia Campani, Dario Marchese, Maria Teresa Pitaro, Michele Pitaro, Paolo Grieco, Development of a liposome-based formulation for vitamin K1 nebulization on the skin. International Journal of Nanomedicine. ,vol. 9, pp. 1823- 1832 ,(2014) , 10.2147/IJN.S58365
T. Cosgrove, T.M. Obey, K. Ryan, Depletion layer measurements using nuclear magnetic resonance for silica dispersions with non-adsorbing poly(styrene sulphonate) Colloids and Surfaces. ,vol. 65, pp. 1- 7 ,(1992) , 10.1016/0166-6622(92)80169-3
Ana Luiza M. da Silva, Renata V. Contri, Denise S. Jornada, Adriana R. Pohlmann, Silvia S. Guterres, Vitamin K1–loaded lipid‐core nanocapsules: physicochemical characterization and in vitro skin permeation Skin Research and Technology. ,vol. 19, ,(2013) , 10.1111/J.1600-0846.2012.00631.X
Jongwon Shim, Hyung Seok Kang, Ih Seop Chang, Won Seok Park, Sang Hun Han, Junoh Kim, Transdermal delivery of mixnoxidil with block copolymer nanoparticles. Journal of Controlled Release. ,vol. 97, pp. 477- 484 ,(2004) , 10.1016/J.JCONREL.2004.03.028
Amir Hossein Saberi, Yuan Fang, David Julian McClements, Fabrication of vitamin E-enriched nanoemulsions: factors affecting particle size using spontaneous emulsification. Journal of Colloid and Interface Science. ,vol. 391, pp. 95- 102 ,(2013) , 10.1016/J.JCIS.2012.08.069
Nicolas Anton, Thierry F. Vandamme, The universality of low-energy nano-emulsification. International Journal of Pharmaceutics. ,vol. 377, pp. 142- 147 ,(2009) , 10.1016/J.IJPHARM.2009.05.014