Primordial Germ Cells in Mouse and Human

摘要: Publisher Summary The germ cell lineage in the mouse is not predetermined, but established during gastrulation, response to signaling molecules acting on a subset of epiblast cells that move through primitive streak together with extra-embryonic mesoderm precursors. terminates differentiation gametes (eggs and spermatozoa). In mammals arises extraembryonic at posterior end streak. During this period, they proliferate steady rate are known as primordial (PGCs). PGCs do any stage constitute stem population: each divisions undergo (9 or 10 mouse, more human) moves them further along their developmental trajectory. After migration site future gonads, sex determination achieved, phenotype male female embryos diverging. Site-specific DNA methylation imprinted genes erased about time entry into new imprints later. Germ respond certain growth factors by proliferating indefinitely. These immortalized embryonic lines chromosomally stable pluripotent, closely resembling derived from blastocyst-stage embryos.