Newborn screening for congenital cytomegalovirus: Options for hospital-based and public health programs

摘要: Abstract Background Congenital cytomegalovirus (CMV) infection is a leading cause of sensorineural hearing loss (SNHL) and developmental disability in children. Early identification infected children through screening could allow for early intervention improvement functional outcomes among the subset who develop sequelae. Objectives To outline potential options strategies newborns congenital CMV to discuss barriers data needs inform future policy decisions. Study design Commentary based on literature expert opinion newborn dried blood spot screening, screening/Early Hearing Detection Intervention (EHDI) programs, CMV. Results Although no population-based underway, pilot studies using variety assays with urine or specimens are underway. Challenges both practical—uncertain sensitivity suitable large-scale lack infrastructure collection specimens; evidentiary—the need demonstrate improved value offset expense adverse psychosocial consequences families whose require periodic monitoring but never Conclusions Screening potentially important that merits additional research, including logistical feasibility different families.