Association of Anti-VEGF Injections with Progression of Geographic Atrophy.

作者: Ryan Enslow , Sai Bhuvanagiri , Sravanthi Vegunta , Benjamin Cutler , Michael Neff

DOI: 10.4137/OED.S38863

关键词:

摘要: Age-related macular degeneration (AMD) is one of the leading causes blindness in developed countries people over age 60 years. One forms advanced AMD wet AMD. Wet a result leakage and bleeding from abnormal neovascularization. The principal treatment for intravitreal anti-VEGF injections. A second form geographic atrophy (GA). GA refers to large areas retinal pigment epithelium loss. In literature, there some concern that injections administered treat may be associated with progression GA. This review discusses evidence suggesting association

参考文章(12)
Daniel F Martin, Maureen G Maguire, GSet al Ying, Juan E Grunwald, Stuart L Fine, Glenn J Jaffe, None, Ranibizumab and bevacizumab for neovascular age-related macular degeneration. The New England Journal of Medicine. ,vol. 364, pp. 1897- 1908 ,(2011) , 10.1056/NEJMOA1102673
Wayne Smith, Jacqueline Assink, Ronald Klein, Paul Mitchell, Caroline C.W Klaver, Barbara E.K Klein, Albert Hofman, Susan Jensen, Jie Jin Wang, Paulus T.V.M de Jong, Risk factors for age-related macular degeneration Ophthalmology. ,vol. 108, pp. 697- 704 ,(2001) , 10.1016/S0161-6420(00)00580-7
Elona Dhrami-Gavazi, Chandrakumar Balaratnasingam, Winston Lee, K. Bailey Freund, Type 1 neovascularization may confer resistance to geographic atrophy amongst eyes treated for neovascular age-related macular degeneration International Journal of Retina and Vitreous. ,vol. 1, pp. 15- 26 ,(2015) , 10.1186/S40942-015-0015-6
Christopher Schütze, Manuela Wedl, Bernhard Baumann, Michael Pircher, Christoph K. Hitzenberger, Ursula Schmidt-Erfurth, Progression of retinal pigment epithelial atrophy in antiangiogenic therapy of neovascular age-related macular degeneration. American Journal of Ophthalmology. ,vol. 159, pp. 1100- 1114 ,(2015) , 10.1016/J.AJO.2015.02.020
grupo estudio VIEW2 HHO Dominguez, None, Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. ,vol. 119, pp. 2537- 2548 ,(2012) , 10.1016/J.OPHTHA.2012.09.006
M. Saint-Geniez, T. Kurihara, E. Sekiyama, A. E. Maldonado, P. A. D'Amore, An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 18751- 18756 ,(2009) , 10.1073/PNAS.0905010106
Soraya Rofagha, Robert B Bhisitkul, David S Boyer, SriniVas R Sadda, Kang Zhang, Seven-Up Study Group, Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology. ,vol. 120, pp. 2292- 2299 ,(2013) , 10.1016/J.OPHTHA.2013.03.046
Robert B. Bhisitkul, Thais S. Mendes, Soraya Rofagha, Wayne Enanoria, David S. Boyer, SriniVas R. Sadda, Kang Zhang, Macular Atrophy Progression and 7-Year Vision Outcomes in Subjects From the ANCHOR, MARINA, and HORIZON Studies: the SEVEN-UP Study∗ American Journal of Ophthalmology. ,vol. 159, pp. 915- 924 ,(2015) , 10.1016/J.AJO.2015.01.032
Juan E Grunwald, Ebenezer Daniel, Jiayan Huang, Gui-shuang Ying, Maureen G Maguire, Cynthia A Toth, Glenn J Jaffe, Stuart L Fine, Barbara Blodi, Michael L Klein, Alison A Martin, Stephanie A Hagstrom, Daniel F Martin, CATT Research Group, Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials. Ophthalmology. ,vol. 121, pp. 150- 161 ,(2014) , 10.1016/J.OPHTHA.2013.08.015
Usha Chakravarthy, Simon P Harding, Chris A Rogers, Susan M Downes, Andrew J Lotery, Lucy A Culliford, Barnaby C Reeves, None, Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial The Lancet. ,vol. 382, pp. 1258- 1267 ,(2013) , 10.1016/S0140-6736(13)61501-9