Anticancer potential of metformin: focusing on gastrointestinal cancers
作者： Morteza Ghasemnejad-Berenji , Mohammad Rafi Khezri , Hassan Melekinejad , Naime Majidi-Zolbanin
DOI: 10.1007/S00280-021-04256-8
关键词:
摘要: Gastrointestinal cancers are one of the most common types cancer that have high annual mortality; therefore, identification and introduction safe drugs in control prevention these particular importance. Metformin, a lipophilic biguanide, is commonly prescribed agent for type 2 diabetes management. In addition to its great effects on lowering blood glucose concentrations, anti-cancer properties this drug been reported many such as gastrointestinal cancers. Hence reduction risk suppression studied different clinical trials. Furthermore, proposed mechanisms metformin preventing growth investigated several studies. review, we discuss recent advances elucidating molecular relevant use treatment.
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