Platelet adhesion to foreign surfaces under controlled conditions of whole blood flow: human vs rabbit, dog, calf, sheep, pig, macaque, and baboon.

摘要: Our results reveal significant differences between mammalian species with respect to platelet adhesion foreign surfaces exposed heparinized, flowing blood. In particular, we have demonstrated the following: 1) At a surface shear rate characteristic of rates in arteries, human (and that calf, baboon, macaque, hog or sheep) is negligible comparison dog rabbit after 10 mins blood flow. 2) The are biomaterial dependent: human-dog difference present Cuprophan Avcothane, but absent compressed Gore-Tex fluorinated ethylcellulose. (The platelets humans and dogs adhere comparable degrees on latter 2 biomaterials.) 3) With recirculated blood, persists at 30 180 mins. 4) By means videomicroscopy, unlikely only be an artifact possible formation embolization surface-adherent aggregates. Tests for thromboresistance candidate biomaterials under controlled flow conditions must therefore begin take into account other species.