Single and Multiple Gene Manipulations in Mouse Models of Human Cancer

摘要: Mouse models of human cancer play a critical role in understanding the molecular and cellular mechanisms tumorigenesis. Advances continue to be made modeling disease mouse, though relevance mouse model often relies on how closely it is able mimic histologic, molecular, physiologic characteristics respective cancer. A classic use genetically engineered studying through overexpression or deletion gene. However, manipulation single gene falls short mimicking all carcinoma humans; thus multiple approach needed. Here we review genetic cancers their abilities recapitulate with versus combinatorial approaches genes commonly involved