Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples.
作者： Václav Ranc , Vladimír Havlíček , Petr Bednar , Karel Lemr
DOI: 10.1255/EJMS.978
关键词:
摘要: A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers one three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine ibuprofen. The initial evaluation systems was carried out by direct infusion solution mixtures (analyte/central metal/chiral reference ligand) to a standard (ESI) source. Cu(II) used as central metal for all analytes, L-phenylalanine applied ligand DOPA, whereas L-tryptophan other two analytes. Then, ESI source substituted nano-DESI dried spots 1 microL whole human blood spiked with individual drugs successfully analyzed without any pre-treatment. Irrespective laborious set-up, combination has, first time, been demonstrated promising tool samples.
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impublications.com 参考文章(29)
Steven H. Y. Wong, Irving Sunshine, Handbook of Analytical Therapeutic Drug Monitoring and Toxicology ,(1997)
Bogdan Gologan, Zoltán Takáts, Robert Graham Cooks, Justin Michael Wiseman, Method and system for desorption electrospray ionization ,(2005)
Guangming Huang, Hao Chen, Xinrong Zhang, R. Graham Cooks, Zheng Ouyang, Rapid screening of anabolic steroids in urine by reactive desorption electrospray ionization. Analytical Chemistry. ,vol. 79, pp. 8327- 8332 ,(2007) , 10.1021/AC0711079
Mario Thevis, Andreas Thomas, Philippe Delahaut, Alain Bosseloir, Wilhelm Schänzer, Doping Control Analysis of Intact Rapid-Acting Insulin Analogues in Human Urine by Liquid Chromatography−Tandem Mass Spectrometry Analytical Chemistry. ,vol. 78, pp. 1897- 1903 ,(2006) , 10.1021/AC052095Z
J. C. Garriott, L. M. Simmons, A. Poklis, M. A. Mackell, Five cases of fatal overdose from caffeine-containing "look-alike" drugs Journal of Analytical Toxicology. ,vol. 9, pp. 141- 143 ,(1985) , 10.1093/JAT/9.3.141
W. Andy Tao, Duxi Zhang, Feng Wang, Peter D. Thomas, R. Graham Cooks, Kinetic Resolution of d,l-Amino Acids Based on Gas-Phase Dissociation of Copper(II) Complexes. Analytical Chemistry. ,vol. 71, pp. 4427- 4429 ,(1999) , 10.1021/AC990530H
Huanwen Chen, Nari N. Talaty, Zoltán Takáts, R. Graham Cooks, Desorption Electrospray Ionization Mass Spectrometry for High-Throughput Analysis of Pharmaceutical Samples in the Ambient Environment Analytical Chemistry. ,vol. 77, pp. 6915- 6927 ,(2005) , 10.1021/AC050989D
Zoltan Takats, Justin M Wiseman, Bogdan Gologan, R Graham Cooks, Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization Science. ,vol. 306, pp. 471- 473 ,(2004) , 10.1126/SCIENCE.1104404
Eugene M Laska, Abraham Sunshine, Ivan Marrero, Nancy Olson, Carole Siegel, Nilda McCormick, The correlation between blood levels of ibuprofen and clinical analgesic response Clinical Pharmacology & Therapeutics. ,vol. 40, pp. 1- 7 ,(1986) , 10.1038/CLPT.1986.129
Duxi Zhang, W.A. Tao, R.Graham Cooks, Chiral resolution of d- and l-amino acids by tandem mass spectrometry of Ni(II)-bound trimeric complexes International Journal of Mass Spectrometry. ,vol. 204, pp. 159- 169 ,(2001) , 10.1016/S1387-3806(00)00330-4