Plasma vitamin B12 status and cerebral white-matter lesions

摘要: Background and objective: Elevated homocysteine has been associated with a higher prevalence of cerebral white-matter lesions infarcts, worse cognitive performance. This raises the question whether factors involved in metabolism, such as vitamin B 12 , are also related to these outcomes. study examined association several markers status lesions, infarcts cognition. Methods: The evaluated plasma concentrations methylmalonic acid, holotranscobalamin transcobalamin saturation at baseline cognition during follow-up among 1019 non-demented elderly participants population-based Rotterdam Scan Study. Analyses were adjusted for potential confounders, including folate concentration. Results: Poorer was significantly greater severity particular periventricular concentration-related manner. Adjustment common vascular risk (including blood pressure, smoking, diabetes intima media thickness) did not alter associations. modestly weakened No observed any studied presence brain or decline follow-up. Conclusions: These results indicate that normal range is especially lesions. Given absence an it hypothesised this explained by effects on myelin integrity rather than through mechanisms.