Escherichia coli strains containing mutations in the structural gene for topoisomerase I are recombination deficient.

DOI: 10.1128/JB.160.3.1168-1170.1984

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摘要: Mutations in the gene encoding topoisomerase I of Escherichia coli were tested for their effect on plasmid recombination. Recombination was decreased 1,000-fold at 30 and 37 degrees C occurred approximately wild-type frequencies 42 C. The suppression topA mutations did not appear to be a result increased activity