Natriuretic peptide system and the heart.

摘要: The natriuretic peptide (NP) family includes atrial (ANP), brain or B-type (BNP) and C-type NP (CNP). A huge number of experimental clinical studies, published in the 1st decade this century, have added further support to hypothesis that endocrine function human heart is a relevant component complex network including endocrine, nervous immune systems. hormones constitute well-integrated regulatory system share similar spectrum biological actions, although there are some differences potency between ANP, BNP CNP. However, several important issues on field need be investigated further. production, secretion peripheral degradation pathways both CNP should clarified detail. In particular, circulating plasma pool prohormone can as precursor active hormone demonstrated definitively. Recent findings indicate processing prohormones could likely submitted rules, which might impaired patients with failure, opening up new perspectives even treatment failure. This suggests novel pharmacological target for drugs inducing and/or modulating maturation into hormone.