Mapping the genetic variation of executive attention onto brain activity

摘要: Brain imaging data have repeatedly shown that the anterior cingulate cortex is an important node in brain network mediating conflict. We previously reported polymorphisms dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time differences Attention Network Test (ANT). To examine whether this genetic variation might contribute to activation within cortex, we genotyped 16 subjects for DRD4 MAOA who had been scanned during ANT. In each two associated more efficient experiments, found a polymorphism which persons allele better behavioral performance significantly while performing ANT than those worse performance. The results demonstrate how among individuals can be linked individual neuromodulators operation appropriate attentional network.