Sex differences in stereotyped behavior in the rat
作者： William W. Beatty , Gerald A. Holzer
DOI: 10.1016/0091-3057(78)90356-8
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摘要: Neurologically intact female rats exhibited more intense and prolonged stereotyped behavior in response to 5 mg/kg doses of d-amphetamine than males. They also displayed greater stimulation activity 1.5 the drug. Prior treatment with intrastriatal injections 6-hydroxydopamine (6HDA) eliminated sex difference but not amphetamine. Neither nor 6HDA treated differed amount elicited by dopamine agonist apomorphine suggesting that amphetamine-elicited stereotypy is result differences strial receptor mechanisms. The present results could arise from amphetamine uptake metabolism which have been described recently although other explanations are possible.
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