Biocompatibility of Ionomeric Cements Modified by Red Propolis: A Morphological and Immunohistochemical Analysis.

摘要: PURPOSE To evaluate the biocompatibility in rat subcutaneous tissue of conventional orthodontic cements, Riva (R) and Meron (M), modified by addition ethanolic extract red propolis (EERP), at different concentrations time intervals. MATERIALS AND METHODS One hundred eight male adult Wistar rats were used, distributed nine groups cements with added EERP used (C-control, MC, M10, M25, M50, RC, R10, R25, R50). The sacrificed after 3 intervals (7, 15, 30 days). Histological immunohistochemical analyses performed. findings statistically analyzed using Kruskal-Wallis test followed Dunn's (p < 0.05). RESULTS highest led to a higher level inflammation initial times 0.05), but without differences days. In terms collagen, there was less collagenization comparison control group C. However, over time, resulted healing compatible that CD68 immunostaining significantly (R50 M50) = 0.001). CONCLUSION Orthodontic found be biocompatible tissue. cement 50% showed inflammation, satisfactory repair.