Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.

摘要: Honokiol (Hon), a polyphenol and main active ingredient from the bark of Magnolia officinalis, has been documented as having multiple pharmacological functions, including neuroprotection. However, mechanisms underlying its neuroprotective effects are not well-defined. In this study, we reported that Hon attenuates H2O2- or 6-hydroxydopamine (6-OHDA)-induced apoptosis PC12 cells by increasing glutathione level upregulating multitude cytoprotective proteins, heme oxygenase 1, NAD(P)H:quinone oxidoreductase thioredoxin reductase 1. Further studies reveal promotes transcription factor Nrf2 nuclear translocation activation. Moreover, cytoprotection was antagonized silence expression, highlighting fact is critically engaged in cellular functions Hon. Taken together, our study identified an effective agonist neuronal system displays potent neuroprotection against oxidativ...