Proliferation of lung cells in chronically hypoxic rats. An autoradiographic and radiochemical study.

摘要: Alveolar hypoxia produces pulmonary hypertension and morphological alterations in the vessels, such as media hypertrophy hyperplasy of arteries well development smooth muscle cells wall small precapillary arteries. Chronic induces an increase DNA-synthesis rate lung tissue this study confirms previously reported result using vivo incorporation 3H-thymidine. Autoradiographic investigations demonstrate 3H-thymidine labelling index bronchial epithelial lining, parenchyma cells, after 9 days exposure to a simulated altitude 4250 m (Pb = 440 Torr).