Extravascular coagulation and fibrinolysis in murine lung inflammation induced by the mycobacterial cord factor trehalose-6,6'-dimycolate.

摘要: Diffuse pulmonary inflammation in interstitial lung diseases is associated with increased coagulation the extravascular spaces of lung. We hypothesized that conditions favoring over fibrinolysis are related to inflammation. Pulmonary and were studied two strains mice susceptible or resistant development response mycobacterial cell wall glycolipid trehalose-6,6'-dimycolate (TDM). Susceptible animals treated TDM intravenously develop well-organized collections mononuclear cells parenchyma referred as granulomas this report. More found ICR than A/J after intravenous administration (7 +/- 1 granulomas/mm2 versus 0.3 granulomas/mm2, p = 0.005). Granuloma formation was procoagulant activity (PCA) measured bronchoalveolar lavage (BAL) lysates from mice. In contrast, TDM-resistant challenged did not have a significant BAL PCA response, but expressed several-fold greater levels fluid plasminogen activator (PAA) To examine role inflammatory C57Bl/10SnJ anticoagulated by oral warfarin prior challenge TDM; these developed fewer TDM-treated without treatment (2.6 0.5 6.5 0.8 < 0.001) had similar changes weights cellularity.(ABSTRACT TRUNCATED AT 250 WORDS)