Three‐dimensional pulmonary perfusion MRI with radial ultrashort echo time and spatial–temporal constrained reconstruction

摘要: Purpose To assess the feasibility of spatial–temporal constrained reconstruction for accelerated regional lung perfusion using highly undersampled dynamic contrast-enhanced (DCE) three-dimensional (3D) radial MRI with ultrashort echo time (UTE). Methods A combined strategy was used to accelerate DCE 3D pulmonary whole coverage. A UTE acquisition an iterative exploiting principal component analysis and wavelet soft-thresholding dimensionality reduction in space time. The performance method evaluated a fractal-based digital phantom. Simulated maps contrast enhancement curves were compared ground truth structural similarity index (SSIM) determine robust threshold regularization levels. Feasibility studies then performed canine human subject (TE = 0.08 ms) mapping perfusion. Results The able accurately recover phantom nominal isotropic spatial resolution 1.5 mm (SSIM 0.949). demonstrated providing artifact-free simple breath-held acquisition. Conclusion The proposed is promising fast flexible imaging. Magn Reson Med 73:555–564, 2015. © 2014 Wiley Periodicals, Inc.