Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.

作者: Qi-Wen Fan , William A. Weiss

DOI: 10.1007/82_2010_67

关键词:

摘要: … Advances in neurosurgical techniques and in radiation therapy continue to benefit patients with glioma. In contrast, the comparatively modest effects of medical therapy pose a challenge…

参考文章(42)
S. Jones, X. Zhang, D. W. Parsons, J. C.-H. Lin, R. J. Leary, P. Angenendt, P. Mankoo, H. Carter, H. Kamiyama, A. Jimeno, S.-M. Hong, B. Fu, M.-T. Lin, E. S. Calhoun, M. Kamiyama, K. Walter, T. Nikolskaya, Y. Nikolsky, J. Hartigan, D. R. Smith, M. Hidalgo, S. D. Leach, A. P. Klein, E. M. Jaffee, M. Goggins, A. Maitra, C. Iacobuzio-Donahue, J. R. Eshleman, S. E. Kern, R. H. Hruban, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. E. Velculescu, K. W. Kinzler, Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses Science. ,vol. 321, pp. 1801- 1806 ,(2008) , 10.1126/SCIENCE.1164368
Susan M. Chang, , Patrick Wen, Timothy Cloughesy, Harry Greenberg, David Schiff, Charles Conrad, Karen Fink, H. Ian Robins, Lisa De Angelis, Jeffrey Raizer, Kenneth Hess, Ken Aldape, Kathleen R. Lamborn, John Kuhn, Janet Dancey, Michael D. Prados, Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Investigational New Drugs. ,vol. 23, pp. 357- 361 ,(2005) , 10.1007/S10637-005-1444-0
J. F. de Groot, M. R. Gilbert, K. Aldape, K. R. Hess, T. A. Hanna, S. Ictech, M. D. Groves, C. Conrad, H. Colman, V. K. Puduvalli, V. Levin, W. K. A. Yung, Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma Journal of Neuro-Oncology. ,vol. 90, pp. 89- 97 ,(2008) , 10.1007/S11060-008-9637-Y
Sauveur-Michel Maira, Frédéric Stauffer, Josef Brueggen, Pascal Furet, Christian Schnell, Christine Fritsch, Saskia Brachmann, Patrick Chène, Alain De Pover, Kevin Schoemaker, Doriano Fabbro, Daniela Gabriel, Marjo Simonen, Leon Murphy, Peter Finan, William Sellers, Carlos García-Echeverría, Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity Molecular Cancer Therapeutics. ,vol. 7, pp. 1851- 1863 ,(2008) , 10.1158/1535-7163.MCT-08-0017
Qi-Wen Fan, Christine K. Cheng, Theodore P. Nicolaides, Christopher S. Hackett, Zachary A. Knight, Kevan M. Shokat, William A. Weiss, A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Research. ,vol. 67, pp. 7960- 7965 ,(2007) , 10.1158/0008-5472.CAN-07-2154
Klaus Okkenhaug, Antonio Bilancio, Géraldine Farjot, Helen Priddle, Sara Sancho, Emma Peskett, Wayne Pearce, Stephen E Meek, Ashreena Salpekar, Michael D Waterfield, Andrew JH Smith, Bart Vanhaesebroeck, Impaired B and T Cell Antigen Receptor Signaling in p110delta PI 3-Kinase Mutant Mice Science. ,vol. 297, pp. 1031- 1034 ,(2002) , 10.1126/SCIENCE.1073560
Takehiko Sasaki, Junko Irie-Sasaki, Russell G Jones, Antonio J Oliveira-dos-Santos, William L Stanford, Brad Bolon, Andrew Wakeham, Annick Itie, Dennis Bouchard, Ivona Kozieradzki, Nicholas Joza, Tak W Mak, Pamela S Ohashi, Akira Suzuki, Josef M Penninger, Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration Science. ,vol. 287, pp. 1040- 1046 ,(2000) , 10.1126/SCIENCE.287.5455.1040
J. M. Stommel, A. C. Kimmelman, H. Ying, R. Nabioullin, A. H. Ponugoti, R. Wiedemeyer, A. H. Stegh, J. E. Bradner, K. L. Ligon, C. Brennan, L. Chin, R. A. DePinho, Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies Science. ,vol. 318, pp. 287- 290 ,(2007) , 10.1126/SCIENCE.1142946
Brendan D. Manning, Lewis C. Cantley, AKT/PKB signaling: navigating downstream. Cell. ,vol. 129, pp. 1261- 1274 ,(2007) , 10.1016/J.CELL.2007.06.009