Emerging Therapeutic Promise of Ketogenic Diet to Attenuate Neuropathological Alterations in Alzheimer’s Disease

摘要: Alzheimer’s disease (AD) is a multifactorial and chronic neurodegenerative disorder that interferes with memory, thinking, behavior. The consumption of dietary fat has been considered a vital factor for AD as this related to blood-brain barrier function cholesterol signaling. e4 allele apolipoprotein E (APOE4) primary genetic risk that encodes one many proteins accountable the transport it deemed leading in brain. In case development, causative high level serum/plasma cholesterol. However, statement arguable and, meantime, levels brain individuals are extremely inconstant do not reflect factor. fact, APOE4 neither fundamental nor sufficient advancement AD; just acts synergistic increases danger AD. Another noticeable characteristic area-specific decreases metabolism glucose. It found cells cannot efficiently metabolize fats; hence, they totally rely upon glucose vitality substrate. Thus, suppression can possess an intense effect on actions. Hypometabolism frequently quite recently achieved impressive consideration plausible target interfering progression disease. One promising approach keep up normal supply ketone bodies from ketogenic diet signifies potential therapeutic agent Therefore, review represents role diets combat pathogenesis by considering influence APOE.