Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
作者： Igor Nikoulin , Douglas L. Rodenburg , Steve J. Bannister , James D. Mcchesney
DOI:
关键词:
摘要: In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from group consisting phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further an agent natural antioxidants, ubiquinol vitamin E, methods for preparing nanoparticles. The disclosed are capable selectively delivering lipophilic drugs prodrugs to cellular targets expressing receptors after intra venous injection.
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