3-(Piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors

作者: Laura Kay Shawver , Klaus Peter Hirth , Li Sun , Gerald McMahon , Peng Cho Tang

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摘要: The present invention relates to novel 3-(piperazinyl-benylidenyl)-2-indolinone compounds and derivatives physiologically acceptable salts thereof which are expected modulate the activity of protein tyrosine kinases therefore be useful in prevention treatment kinase related cellular disorders such as cancer.

参考文章(72)
S.P. Singh, Krishna Jha, Indolinone derivatives as potential antimicrobial agents. Zentralblatt für Mikrobiologie. ,vol. 144, pp. 105- 109 ,(1989) , 10.1016/S0232-4393(89)80073-3
M B Goldring, S R Goldring, Cytokines and cell growth control. Critical Reviews in Eukaryotic Gene Expression. ,vol. 1, pp. 301- 326 ,(1991)
Floege J, Young Ba, Eng E, Johnson Rj, Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo. Kidney International. ,vol. 39, ,(1993)
V M Macaulay, M J Everard, I E Smith, J D Teale, J J Van Wyk, P A Trott, J L Millar, Autocrine Function for Insulin-like Growth Factor I in Human Small Cell Lung Cancer Cell Lines and Fresh Tumor Cells Cancer Research. ,vol. 50, pp. 2511- 2517 ,(1990)
A. Graziani, D. Gramaglia, P. dalla Zonca, P.M. Comoglio, Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger Journal of Biological Chemistry. ,vol. 268, pp. 9165- 9168 ,(1993) , 10.1016/S0021-9258(18)98327-4
G. Superti-Furga, S. Fumagalli, M. Koegl, S.A. Courtneidge, G. Draetta, Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. The EMBO Journal. ,vol. 12, pp. 2625- 2634 ,(1993) , 10.1002/J.1460-2075.1993.TB05923.X
Angelo Crugnola, Franco Buzetti, Dario Ballinari, Felicita Greco, Vinylene-azaindole derivatives and process for their preparation ,(1993)
Michael A. Eissenstat, Mark P. Wentland, John D. Weaver, Gee-Hong Kuo, 1-cyclopropyl-4-pyridyl-quinolinones ,(1992)
Renato Baserga, The Insulin-like Growth Factor I Receptor: A Key to Tumor Growth? Cancer Research. ,vol. 55, pp. 249- 252 ,(1995)