Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagenesis de regiones variables
作者： Marta Ayala Avila , Gertrudis Rojas Dorantes , Jorge Víctor Gavilondo Cowley , Humberto Lamdan Ordas , Yasmiana Muñoz Pozo
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摘要: La presente invencion revela anticuerpos recombinantes humanos que reconocen el Factor de Crecimiento del Endotelio Vascular-A (VEGF-A) humano, bloquean su interaccion con receptor VEGFR2, e interfieren sus efectos proliferativos in vitro y pro-angiogenicos vivo. Estos identifican un epitope en VEGF-A humano diferente a cualquier otro reportado antes se obtuvieron combinando una misma region variable cadena ligera inmunoglobulinas, otras tres pesada. Los mediante mutagenesis regiones variables inmunoglobulinas humanas, pueden emplearse para la inmunoterapia entidades patologicas cuyo curso este asociado al aumento vasculatura, tales como degeneracion macular asociada edad, cancer otras.
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