2-Acetylpyridine thiosemicarbazones. 4. Complexes with transition metals as antimalarial and antileukemic agents.

摘要: Reaction of the 2-acetylpyridine thiosemicarbazones, 3-azabicyclo[3.2.2]nonane-3-thiocarboxylic acid 2-[1-(2-pyridyl)ethylidene]hydrazide (IIIa), its selenium analogue (IIIb), 1H-hexahydroazepine-1-thiocarboxylic (IV), and 1H-octahydroazocine-1-thiocarboxylic (V) with Cu(II), Ni(II), Fe(III), Mn(II) salts gave crystalline complexes. Relative to free ligands, these complexes show reduced antimalarial activity in mice infected Plasmodium berghei; however, antileukemic properties are enhanced by coordination above-mentioned metals.