What can light scattering spectroscopy do for membrane-active peptide studies?

摘要: Highly charged peptides are important components of the immune system and belong to an family antibiotics. Although their therapeutic activity is known, most molecular level mechanisms controversial. A wide variety different approaches usually applied understand mechanisms, but light scattering techniques frequently overlooked. Yet, a noninvasive technique that allows insights both on peptide mechanism action as well development new Dynamic (DLS) static (SLS) used measure aggregation process lipid vesicles upon addition properties (shape, weight). The high charge these electrostatic attraction toward vesicles, which studied by zeta potential (ζ-potential) measurements. Copyright © 2008 European Peptide Society John Wiley & Sons, Ltd.