M current mystery messenger revealed
作者： Stephen R Ikeda , Paul J Kammermeier
DOI: 10.1016/S0896-6273(02)00792-4
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摘要: Abstract The identity of signaling elements that couple muscarinic acetylcholine receptor (mAChR) activation to M current (KCNQ K + channels) modulation has remained unknown despite decades study. Suh and Hille (in this issue Neuron ) demonstrate phospholipase C (PLC) initiates recovery requires ATP phosphoinositide 4-kinase (PI 4-K). These data suggest breakdown phosphotidylinositol 4,5-bisphosphate (PIP 2 is a crucial determinant channel modulation.
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sci-hub.se 参考文章(11)
Hong-Sheng Wang, Zongming Pan, Wenmei Shi, Barry S Brown, Randy S Wymore, Ira S Cohen, Jane E Dixon, David McKinnon, KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel Science. ,vol. 282, pp. 1890- 1893 ,(1998) , 10.1126/SCIENCE.282.5395.1890
Laurent Bernheim, David J. Beech, Bertil Hille, A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons. Neuron. ,vol. 6, pp. 859- 867 ,(1991) , 10.1016/0896-6273(91)90226-P
Mark S Shapiro, Lonnie P Wollmuth, Bertil Hille, Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. Neuron. ,vol. 12, pp. 1319- 1329 ,(1994) , 10.1016/0896-6273(94)90447-2
Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger. Proceedings of The Royal Society B: Biological Sciences. ,vol. 250, pp. 119- 125 ,(1992) , 10.1098/RSPB.1992.0139
H. Cruzblanca, D.-S. Koh, B. Hille, Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neurons Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 7151- 7156 ,(1998) , 10.1073/PNAS.95.12.7151
Byung-Chang Suh, Bertil Hille, Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron. ,vol. 35, pp. 507- 520 ,(2002) , 10.1016/S0896-6273(02)00790-0
Barry S Brown, Shan Ping Yu, Modulation and genetic identification of the M channel Progress in Biophysics & Molecular Biology. ,vol. 73, pp. 135- 166 ,(2000) , 10.1016/S0079-6107(00)00004-3
D. A. Brown, P. R. Adams, Muscarinic suppression of a novel voltage-sensitive K + current in a vertebrate neurone Nature. ,vol. 283, pp. 673- 676 ,(1980) , 10.1038/283673A0
P R Adams, D A Brown, Synaptic inhibition of the M-current: slow excitatory post-synaptic potential mechanism in bullfrog sympathetic neurones. The Journal of Physiology. ,vol. 332, pp. 263- 272 ,(1982) , 10.1113/JPHYSIOL.1982.SP014412
Neil V. Marrion, CONTROL OF M-CURRENT Annual Review of Physiology. ,vol. 59, pp. 483- 504 ,(1997) , 10.1146/ANNUREV.PHYSIOL.59.1.483