Modeling the impact of single-cell stochasticity and size control on the population growth rate in asymmetrically dividing cells

摘要: Abstract Microbial populations show striking diversity in cell growth morphology and lifecycle [1]; however, our understanding of how these factors influence the rate remains limited. We use theory simulations to predict impact asymmetric division, size regulation single-cell stochasticity on population rate. Our model predicts that coarse-grained noise λ decreases rate, as previously seen for symmetrically dividing cells [2]. However, a given we find asymmetrically can enhance with strong control (between “sizer” an “adder”). To reconcile this finding abundance organisms nature, propose additional constraints division must be present which are not included model, explore effects selected extensions thereof. Further, within epigenetically inherited generation times may arise due cells, providing possible explanation recent experimental observations budding yeast [3]. Taken together, findings provide insight into complex generated by non-canonical morphologies.