Gene expression as peripheral biomarkers for sporadic Alzheimer's disease.
作者： Edna Grünblatt , Jasmin Bartl , Sonja Zehetmayer , Thomas M. Ringel , Peter Bauer
关键词:
摘要: Alzheimer's disease (AD), the most common cause of dementia, is a progressive neurodegenerative disease. At present, diagnosis AD rather late in Therefore, we attempted to find peripheral biomarkers for early AD. We investigated profiles 33 genes, previously found by our group have altered expression postmortem brains The gene were studied via quantitative-real-time-reverse-transcription-polymerase-chain-reaction, whole blood samples (collected with PAXgene RNA system) isolated from population clinically diagnosed and healthy controls (1-year period/ up 4 samples). Five genes showed significant correlation dementia score, Mini-Mental State Examination (MMSE). Focusing on two smallest p-value, H3-histone cannabinoid-receptor-2, notable increases these mRNA subjects lower MMSE scores. Seasonal variations not due sample size, but did seem vary time withdrawal. In conclusion, profiling might be promising method investigating large aim developing an
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